IFAA: Robust Inference for Absolute Abundance in Microbiome Analysis

IFAA is a robust approach to make inference on the association of covariates with the absolute abundance (AA) of microbiome in an ecosystem. It can be also directly applied to relative abundance (RA) data to make inference on AA because the ratio of two RA is equal ratio of their AA. This algorithm can estimate and test the associations of interest while adjusting for potential confounders. High-dimensional covariates are handled with regularization. The estimates of this method have easy interpretation like a typical regression analysis. High-dimensional covariates are handled with regularization and it is implemented by parallel computing. False discovery rate is automatically controlled by this approach. Zeros do not need to be imputed by a positive value for the analysis. The IFAA package also offers the 'MZILN' function for estimating and testing associations of abundance ratios with covariates.

Version: 1.0.6
Depends: R (≥ 3.6.0)
Imports: qlcMatrix (≥ 0.9.7), methods (≥ 3.3.0), mathjaxr (≥ 1.0-1), expm (≥ 0.999-3), foreach (≥ 1.4.3), Matrix (≥ 1.4-0), HDCI (≥ 1.0-2), parallel (≥ 3.3.0), doParallel (≥ 1.0.11), future (≥ 1.12.0), glmnet, stats
Suggests: knitr, rmarkdown
Published: 2022-04-13
Author: Quran Wu [aut], Zhigang Li [aut, cre]
Maintainer: Zhigang Li <zhigang.li at ufl.edu>
License: GNU General Public License version 2
URL: https://github.com/gitlzg/IFAA, https://arxiv.org/abs/1909.10101v3, https://link.springer.com/article/10.1007/s12561-018-9219-2
NeedsCompilation: no
Materials: README NEWS
CRAN checks: IFAA results

Documentation:

Reference manual: IFAA.pdf
Vignettes: IFAA

Downloads:

Package source: IFAA_1.0.6.tar.gz
Windows binaries: r-devel: IFAA_1.0.6.zip, r-release: IFAA_1.0.6.zip, r-oldrel: IFAA_1.0.6.zip
macOS binaries: r-release (arm64): IFAA_1.0.6.tgz, r-oldrel (arm64): IFAA_1.0.6.tgz, r-release (x86_64): IFAA_1.0.6.tgz, r-oldrel (x86_64): IFAA_1.0.6.tgz
Old sources: IFAA archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=IFAA to link to this page.